Harlequin Cells

Created 11 April 2024

What Are Harlequin Cells?

Harlequin cells are dysplastic eosinophils with large purple-violet granules resembling basophilic granules. The literature would have me believe that they are commonly observed in acute and chronic myeloid leukaemias… I probably have seen them before but I can’t say I remember seeing one.

 

A purple and white cell

Description automatically generated

 

 

This one was in the blood film of a chap with CLL whose white cell count was over 100.

I only saw the one despite some serious searching for more

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Some More Expert Opinion…

 

https://journals.lww.com/hemasphere/abstract/2019/06001/pb1991_harlequin_cell__ubiquitous_or.1861.aspx

https://onlinelibrary.wiley.com/doi/full/10.1002/jha2.576

https://imagebank.hematology.org/image/64665/harlequin-cells

https://ashpublications.org/blood/article/132/7/766/39437/Harlequin-cells