Harlequin Cells
Created 11 April 2024
What Are Harlequin Cells?
Harlequin cells are
dysplastic eosinophils with large purple-violet granules resembling basophilic
granules. The literature would have me believe that they are commonly observed
in acute and chronic myeloid leukaemias… I probably have seen them before
but I can’t say I remember seeing one.

This one was in the blood film of a chap with CLL whose white cell count
was over 100.
I only saw the one despite some serious searching for more
Some More Expert Opinion…
https://onlinelibrary.wiley.com/doi/full/10.1002/jha2.576
https://imagebank.hematology.org/image/64665/harlequin-cells
https://ashpublications.org/blood/article/132/7/766/39437/Harlequin-cells